Bevirimat是一种 HIV-1 成熟抑制剂，可在病毒体成熟过程中阻断 Gag 衣壳 (CA) 前体 CA-SPI 裂解为成熟的 CA 蛋白。

Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.

PA-457 reduced viral load in HIV-infected adults in a dose-dependent fashion, when given in a single oral dose in a clinical study[1].

174022-42-5

C36H56O6

584.838

MPC-4326;PA-457;YK FH312;贝韦立马

DMSO:50 mg/mL (85.49 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years