Strictosamide 具有抗炎、抗疟原虫和抗真菌活性。

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

At 20 and 40 mg/kg, strictosamide obviously decreased the TPA-induced mice ear edema (24.7 and 28.1% inhibition, respectively), and significantly inhibited acetic acid-stimulated peritoneal vascular permeability in mice (23.3 and 33.4% inhibition, respectively).?It also significantly decreased the leukocytes in the mice peritoneal cavity induced by CMC-Na at all the tested doses (46.0, 49.1, and 58.7% inhibition, respectively).?To acetic acid-induced writhing test in mice, strictosamide markedly prolonged the pain latency at 20 and 40 mg/kg and decreased the writhing counts at 40 mg/kg (49.7% inhibition).?However, it did not obviously improve the pain threshold of mice in hot-plate test[2].

23141-25-5

C26H30N2O8

498.53

异长春花苷内酰胺

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years