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Zerumbone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zerumbone图片
CAS NO:471-05-6
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
花薑酮
球姜酮
产品介绍
Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离的一种单环倍半萜烯,可有效抑制Epstein-Barr 病毒的激活,IC50为 0.14 mM,具有抗癌、抗炎、抗氧化和抗增殖的作用。

产品描述

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.

体内活性

Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation.

动物实验

Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone.

Cas No.

471-05-6

分子式

C15H22O

分子量

218.34

别名

花薑酮;球姜酮

储存和溶解度

DMSO:44 mg/mL (201.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years