Bisdemethoxycucurmin 是一种具有抗炎及抗氧化作用的姜黄素。

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

24939-16-0

C19H16O4

308.33

双去甲氧基姜黄素;Curcumin III;Didemethoxycurcumin

DMSO:10 mg/mL
Ethanol:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years