5,7-Dihydroxychromone 是一种Cudrania tricuspidata的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的Caspase-3，Caspase-9以及切割的PARP表达。

1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal . 3. 5, 7-Dihydroxychromone induces the translocation of Nrf2 to the nucleus and increases Nrf2/ARE binding activity which results in the up-regulation of the expression of Nrf2-dependent antioxidant genes, including HO-1, NQO1, and GCLc.

31721-94-5

C9H6O4

178.143

5,7-二羟基色酮;5,7-二羟基色原酮;5,7-Dihydroxy-4H-Chromen-4-One

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years