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Procyanidin B1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Procyanidin B1图片
CAS NO:20315-25-7
包装与价格:
包装价格(元)
5 mg电议
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
原花青素 B1
原花青素B1
产品介绍
Procyanidin B1 是水果中常见的多酚类黄酮,能够与TLR4/MD-2复合体结合,具有抗炎活性。

产品描述

Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.

体外活性

Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells [1]. Procyanidin B1 (50-100 μM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at concentrations of 30, 50, and 100 μM and caspase-9 at concentrations of 10, 30, 50, and 100 μM [2]. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα [3].

细胞实验

To investigate the cytotoxic effect of Procyanidin B1, the viability of THP1 cells is assessed using the CCK8 assay. THP1 cells are treated with Procyanidin B1 for 18 h, and 10 μL of CCK8 solution is then added to each well and the cultures are incubated for 4 h at 37°C. The optical density (OD) at 450 nm is measured using an ELx808 Absorbance Microplate Reader. The Procyanidin B1 concentration tested ranges from 50 to 200 μg/mL. Each sample is tested in triplicate [1].

Cas No.

20315-25-7

分子式

C30H26O12

分子量

578.52

别名

原花青素 B1;原花青素B1

储存和溶解度

DMSO:23 mg/mL (39.76 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years