Brevilin A 是从Centipeda minima中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/Akt/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT信号通路抑制剂，通过减弱 JAK 信号和 阻塞 STAT3 信号起作用。

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

In vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima.?The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).?

16503-32-5

C20H26O5

346.42

DMSO:100 mg/mL (288.67 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years