Isoborneol是存在于许多药用植物精油中的一种单萜醇，具有抗氧化和抗病毒特性，是 1 型单纯疱疹病毒(HSV-1)的有效抑制剂。

Isoborneol is a monoterpene alcohol, with neuroprotective and antiviral activities

Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1).?First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption.?Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines.?Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data:?(1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol,?a stereoisomer of isoborneol, did not inhibit HSV-1 glycosylation[1].

124-76-5

C10H18O

154.253

DL-Isoborneol;异龙脑;异冰片

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years