Levomenol 是一种单环倍半萜醇，具有有神经保护、抗氧化、抗炎和抗凋亡的作用。它可减轻三叉神经性疼痛啮齿动物模型的伤害性行为和中枢敏感性。它通过减少小鼠永久性局灶性脑缺血诱导的促炎标志物，防止神经元损伤和记忆缺陷。

Levomenol is a sesquiterpene alcohol that has been found in the essential oils of several aromatic plants, with exerts antioxidant, anti-inflammatory, and anti-apoptotic activities.

(-)-α-bisabolol was able to activate a programmed cell death process in the promastigote stage of the parasite.?It causes phosphatidylserine externalization and membrane damage.?Moreover, it decreases the mitochondrial membrane potential and total ATP levels.?These results highlight the potential use of (-)-α-bisabolol against both L. amazonensis and L. infantum, and further studies should be undertaken to establish it as novel leishmanicidal therapeutic agents[1].

Levomenol inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells[2].

23089-26-1

C15H26O

222.372

(-)-α-红没药醇;(-)-α-BISABOLOL;没药醇

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years