5-hydroxy-7,8-dimethoxyflavone 是一种从雪莲中分离出来的类黄酮，具有抗缺氧和抗炎作用。

5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.

5-hydroxy-7,8-dimethoxyflavone significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells[1].

5-hydroxy-7,8-dimethoxyflavone can significantly prolong the survival time of hypoxic mice[2].

The chemical constituents, isolated and purified by column chromatography from Saussurea invo lucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice[2].

3570-62-5

C17H14O5

298.294

5-hydroxy-7,8-dimethoxyflavone;5-羟基-7,8-二甲氧基黄酮

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years