Isoescin IB 是 Escin IB 的异构体，两者是 Escin 中的主要活性成分。

Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

Five groups of Wistar rats (n=6 per group) were treated with either an intravenous (IV) dose (2.78mg/kg) of sodium escinate (corresponding to 0.5mg/kg of Escin IB and 0.5mg/kg of Isoescin IB), an IV dose (0.5mg/kg) and an oral dose (4mg/kg) of pure Escin IB or Isoescin IB. The administration of sodium escinate, which contains the two isomers, gave rise to higher terminal phase half-life (t1/2) and mean residence time (MRT) values for both Escin IB and Isoescin IB compared to the corresponding compounds administered alone. The absorption of Escin IB and Isoescin IB was very poor, with the oral bioavailability (F) values of<2% observed for both compounds. The two compounds were found to isomerize in vivo, wherein the conversion of Escin IB to Isoescin IB was much easier than that of Isoescin IB to Escin IB[1].

219944-46-4

C55H86O24

1131.26

DMSO:100 mg/mL (88.40 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years