Kaempferol 3-neohesperIDOside 是一种类黄酮，对大鼠比目鱼肌具有拟胰岛素作用。

Kaempferol 3-neohesperidoside is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.

A stimulatory effect of Kaempferol 3-neohesperidoside ( 1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100 nM of this flavonoid glycoside, respectively. The concentration-response curve of insulin showed a stimulatory effect at 3.5 and 7.0 nM (42% and 50%) on glucose uptake when compared with the control group. The effect of Kaempferol 3-neohesperidoside on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC). However, no significant change occurred on glucose uptake stimulated by Kaempferol 3-neohesperidoside when muscles were pretreated with PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and cycloheximide, an inhibitor of protein synthesis. Kaempferol 3-neohesperidoside and insulin (7 nM) did not show a synergistic effect on glucose uptake. Additionally, 100 mg/kg of Kaempferol 3-neohesperidoside by oral gavage was able to increase glycogen content in the muscle[1]

32602-81-6

C27H30O15

594.52

堪非醇 3-新橙皮糖苷;Kaempferol 3-O-neohesperidoside

DMSO:55 mg/ml (92.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years