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Phellamurin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phellamurin图片
CAS NO:52589-11-4
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Phellamurin 是一种来自黄檗叶的黄酮糖苷,可诱导细胞凋亡,具有抗肿瘤活性。它抑制肠道 P-糖蛋白,还抑制凤蝶的产卵。

产品描述

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.

体外活性

Administration of 0-10?μg/mL Phellamurin for 48 hours in U2OS and Saos-2?cells leads to a repression of cell viability dose-dependently, promotes the apoptosis of U2OS and Saos-2?cells concentration-dependently, and declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells[1].

体内活性

Intraperitoneal injection of 50?mg/kg/day Phellamurin daily for 21 days in female BALB/c nude mice represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1].

Cas No.

52589-11-4

分子式

C26H30O11

分子量

518.51

储存和溶解度

DMSO:55 mg/ml (106.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years