Kaurenoic acid 是一种二萜，来源于Sphagneticola trilobata中，可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路，并抑制炎症疼痛。

Kaurenoic acid has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part, by the opening of ATP-sensitive potassium channels. Kaurenoic acid exhibits an analgesic effect in a consistent manner and that its mechanisms involve the inhibition of cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. Kaurenoic acid derivatives have an antimicrobial activity of substituted on carbon-15 at concentrations greater than or equal to 250 μg/ml. Kaurenoic acid has inhibitory effects on the LPS-induced inflammatory response in RAW264.7 macrophages.

6730-83-2

C20H30O2

302.458

异贝壳杉烯酸;kaurenoate;Kauren-19-Oic Acid;kaur-16-en-18-oic acid

DMSO:55 mg/mL(181.8 mM)
Chloroform:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years