Sanguisorbigenin 抑制耐甲氧西林金黄色葡萄球菌，是一种天然抗菌剂。

Sanguisorbigenin is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).

Treatment of Sanguisorbigenin with sub-MIC concentrations (1.56-6.25 μg/mL) significantly inhibited the expression of blaR1, mecA, and blaZ in MRSA dose-dependently. The gene expression of mecA is remarkably reduced after the treatment of Sanguisorbigenin. The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decreasing PBP2a expression[1].

6812-98-2

C30H46O3

454.68

3β-Hydroxyurs-12,19-dien-28-oic acid;Tomentosolic acid;地榆皂苷元;Ursa-12,19-dien-28-oic acid;19-Dehydroursolic acid

DMSO:60 mg/ml (127.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years