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Gelsevirine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gelsevirine图片
CAS NO:38990-03-3
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
钩吻绿碱
产品介绍

产品描述

Gelsevirine has anxiolytic activity, may be via the agonist action of glycine receptor in the brain.

体外活性

Four alkaloid compounds were assessed for cytotoxic activity using the microculture 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay for cellular viability. The results showed that Koumine,Gelsemine,Gelsenicine and Gelsevirine could significantly inhibite the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner.The 50% inhibiting concentration(IC50)of Koumine,Gelsemine,Gelsenicine and Gelsevirine on SW480 cells were 0.45±0.10,0.76±0.28,0.52±0.22 and 1.41±0.06 mmol·L-1 respectively,and were 0.82±0.19,1.20±0.33,1.14±0.23 and1.22±0.11 mmol·L-1 respectively on MGC80-3 cells.Koumine,Gelsemine and Gelsenicine also could inhibite the proliferation of TE-11 and HepG2 cells in a dose-dependent manner.IC50 of Koumine,Gelsemine and Gelsenicine on TE-11 cells were 0.74±0.05,1.94±0.30 and 1.73±0.35 mmol·L-1 respectively,and were 1.26±0.32,1.82±0.35 and 1.79±0.54 mmol·L-1 respectively on HepG2 cells.

Cas No.

38990-03-3

分子式

C21H24N2O3

分子量

352.43

别名

钩吻绿碱

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years