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Chimonanthine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chimonanthine图片
CAS NO:5545-89-1
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍

产品描述

(-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

体外活性

From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-Chimonanthine (1, IC50 = 0.93 μM), (-)-folicanthine (2, 1.4 μM), and (-)-calycanthidine (3, 1.8 μM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. The most potent alkaloid (1) inhibited both tyrosinase and tyrosine-related protein-1 mRNA expressions, to which the melanogenesis inhibitory activity would be ascribable.

Cas No.

5545-89-1

分子式

C22H26N4

分子量

346.47

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years