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Alliin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alliin图片
CAS NO:556-27-4
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(S)-3-(Allylsulphinyl)-L-alanine
蒜氨酸
产品介绍
Alliin 是一种从大蒜中提取的亚砜化合物,具有口服活性,表现出降血糖、抗氧化和抗炎特性。

产品描述

Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. Alliin might be used as an anti-inflammatory agent in the treatment of ALI.

体内活性

LPS-induced ALI was induced in BALB/c mice by intranasal instillation of LPS.?Alliin was administered intraperitoneally to mice 1 h after LPS treatment.?Alliin markedly inhibited lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio induced by LPS.?Alliin also inhibited TNF-α and IL-1β in the bronchoalveolar lavage fluid (BALF) induced by LPS.?Furthermore, LPS-induced lung pathological injury was attenuated by treatment of alliin.?LPS-induced NF-κB activation was significantly inhibited by alliin.?In addition, the expression of peroxisome proliferator-activated receptor γ (PPARγ) was up-regulated by treatment of alliin.?Taken together,Alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response.

Cas No.

556-27-4

分子式

C6H11NO3S

分子量

177.22

别名

(S)-3-(Allylsulphinyl)-L-alanine;蒜氨酸

储存和溶解度

DMSO:3 mg/mL (16.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years