Chelerythrine 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BCLXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BCLXL 取代了 Bax。它诱导细胞凋亡和自噬。

1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiproliferative and antitumor effects.

34316-15-9

C21H18NO4

348.377

Broussonpapyrine;Cheleritrine;Toddalin;白屈菜红碱

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years