Stylopine hydrochloride 是一种生物碱类化合物，从紫堇属之植物块茎中分离得到，具有抗炎症和抗寄生虫作用。

Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.

96087-21-7

C19H18ClNO4

359.81

DMSO:5 mg/mL (13.89 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years