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Stylopine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Stylopine hydrochloride图片
CAS NO:96087-21-7
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
Stylopine hydrochloride 是一种生物碱类化合物,从紫堇属之植物块茎中分离得到,具有抗炎症和抗寄生虫作用。

产品描述

Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.

体外活性

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.

Cas No.

96087-21-7

分子式

C19H18ClNO4

分子量

359.81

储存和溶解度

DMSO:5 mg/mL (13.89 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years