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7-Epi 10-desacetyl paclitaxel
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7-Epi 10-desacetyl paclitaxel图片
CAS NO:78454-17-8
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
10-Deacetyl-7-epipaclitaxel
7-表-10-去乙酰基云南紫杉宁A
7-Epi-10-deacetyltaxol
产品介绍
7-Epi 10-desacetyl 是紫杉醇衍生物,对 HeLa 细胞具有细胞毒性(IC50:85 μM)。

产品描述

7-Epi-10-deacetyltaxol shows IC50 values of 0.085 nM, against HeLa cells.

体外活性

7-Epi-10-deacetyltaxol(EDT) exhibited significant in vitro cytotoxicity in HepG2 cells.Nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT.?Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle.?Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage[1].

细胞实验

The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1].

Cas No.

78454-17-8

分子式

C45H49NO13

分子量

811.881

别名

10-Deacetyl-7-epipaclitaxel;7-表-10-去乙酰基云南紫杉宁A;7-Epi-10-deacetyltaxol

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years