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Oxysanguinarine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxysanguinarine图片
CAS NO:548-30-1
包装与价格:
包装价格(元)
5 mg电议
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
氧化血根碱
Hydroxysanguinarine
8-Oxosanguinarine
产品介绍
Oxysanguinarine是一种来自Meconopsis simplicifolia的小檗生物碱,具有抗疟和抗血小板聚集活性,对登革热病毒具有潜在的抑制作用。

产品描述

Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.

体外活性

A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in humans for a long-time. The ADMET studies, molecular docking and density functional theory (DFT) based analysis was carried out to determine the potential inhibitory properties of these phytochemicals. The ADMET analysis and docking results revealed nine phytochemicals, i.e. Silymarin, Flavobion, Derrisin, Isosilybin, Mundulinol, Silydianin, Isopomiferin, Narlumicine and Oxysanguinarine to have potential inhibitory properties against DENV and can be considered for additional in vitro and in vivo studies to assess their inhibitory effects against DENV replication. They exhibited binding affinity ≥ -8 kcal/mol against DENV4-NS4B. Furthermore, DFT-based analysis revealed high reactivity for these nine phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap. INTERPRETATION &[1]

Cas No.

548-30-1

分子式

C20H13NO5

分子量

347.32

别名

氧化血根碱;Hydroxysanguinarine;8-Oxosanguinarine

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years