Decursin 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。

1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 induced NOX activation and Smad signaling. 3. Decursin has anti-cancer activity , mediated suppression of the PKCα, MAPK and NF-κB pathways in MCF-7 cells. 4. Decursin exhibits cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity.

5928-25-6

C19H20O5

328.364

Decursinol angelate;(+)-Decursin;紫花前胡素;前胡素

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:60 mg/mL(182.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years