Cinnamic acid 在癌症干预中具有潜在的应用价值,对胶质母细胞瘤,黑色素瘤,前列腺癌,肺癌细胞的IC50=1-4.5 mM。
产品描述
Cinnamic acid has potential use in cancer intervention,The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
体内活性
Oinnamic acid?exerts anti-diabetic activity by improving glucose tolerance in vivo and stimulating insulin secretion in vitro.
动物实验
Non-obese type 2 diabetes was developed by injecting 90 mg/kg streptozotocin in 2-day-old Wistar pups. Cinnamic acid and cinnamaldehyde were administered orally to diabetic rats for assessing acute blood glucose lowering effect and improvement of glucose tolerance. Additionally, insulin secretory activity of cinnamic acid and cinnamaldehyde was evaluated in isolated mice islets. Cinnamic acid, but not cinnamaldehyde, decreased blood glucose levels in diabetic rats in a time- and dose-dependent manner. Oral administration of cinnamic acid with 5 and 10 mg/kg doses to diabetic rats improved glucose tolerance in a dose-dependent manner. The improvement by 10 mg/kg cinnamic acid was comparable to that of standard drug glibenclamide (5 mg/kg).
Cas No.
621-82-9
分子式
C9H8O2
分子量
148.16
别名
β-Phenylacrylic acid;3-Phenylacrylic acid;肉桂酸
储存和溶解度
Ethanol:50 mg/mL (337.47 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years