Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3，JNK 和 ERK1/2 的磷酸化，提高 IκB 和 NF-Κb (p65) 的磷酸化水平，抑制 NF-Κb (p65) 的核转位，降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡，具有抗炎作用。

1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-inflammatory activity through modulating multiple cellular behaviors and signaling pathways, leading to the suppression of the adaptive immune response.

50298-90-3

C30H48O7

520.707

雪胆素乙;葫芦素IIB

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years