Methylsticin 是一种卡瓦内酯,从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
产品描述
Methysticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.
体外活性
The kavalactones, and compositions thereof, are useful in mediating osteoclast activity, and as such, are useful in treating or preventing disease or disease symptoms mediated by osteoclast activity.
Cas No.
495-85-2
分子式
C15H14O5
分子量
274.27
别名
Methysticin;麻醉椒苦素
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years