N-Nornuciferine hydrochloride(4846-19-9 free base) 是荷叶中的一种aporphine 生物碱，显着抑制CYP2D6（IC50：3.76 μM，Ki：2.34 μM）。

N-Nornuciferine is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).

N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan O-demethylation (Ki: 2.34 μM).

TQ0296L

C18H20ClNO2

317.81

N-Nornuciferine hydrochloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years