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Pinostrobin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pinostrobin图片
CAS NO:480-37-5
包装与价格:
包装价格(元)
5 mg电议
20 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
PiNOStrobin 是一种PCSK9抑制剂,可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物,并具有抗氧化,抗炎,抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。

产品描述

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis.

体外活性

Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom[1]

Cas No.

480-37-5

分子式

C16H14O4

分子量

270.28

储存和溶解度

DMSO:60 mg/ml (221.98 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years