Triacanthine 是植物生长调节剂。

Triacanthine, which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic.

Triacanthine significantly inhibited EJ cell proliferation (IC50 600?μM). Flow cytometry analysis revealed that cells were arrested in the G1 phase, and apoptotic cells accumulated in the sub-G1 phase in a dose-dependent manner. Triacanthine inhibited the G1-S transition by deterring complex formation between cyclin-dependent kinases and cyclins, thereby up-regulating cell cycle inhibitors p21WAF1 and p27KIP1.

In an in vivo study, triacanthine significantly limited growth of xenografted tumors. Interestingly, while cisplatin resulted in significant weight loss after a 5-mg/kg dose, triacanthine did not cause weight loss, behavioral abnormalities, altered biochemical parameters, or tissue staining. A single oral dose acute-toxicity test (triacanthine 2,000?mg/kg) produced no adverse cytotoxic effects via blood biochemical tests and tissue-organ staining.

2365-40-4

C10H13N5

203.25

异戊烯腺嘌呤; 三刺皂荚碱;Triacanthine;N6-(2-lsopentenyl)adenine

DMSO:40 mg/mL (196.81 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years