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Physalin F
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Physalin F图片
CAS NO:57423-71-9
包装与价格:
包装价格(元)
10 mg电议
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
酸浆苦素 F
酸浆苦味素F
产品介绍
Physalin F 是一种分泌型甾体,诱导人外周血单个核细胞凋亡,降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生,具有强烈抗炎和免疫调节作用。

产品描述

Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection

体内活性

Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities.?A concentration-dependent inhibition of spontaneous proliferation of PBMC from HAM/TSP subjects was observed in the presence of physalin F, as evaluated by (3)H-thymidine uptake.?The IC50 for physalin F was 0.97 0.11 μM.?Flow cytometry analysis using Cytometric Bead Array (CBA) showed that physalin F (10 μM) significantly reduced the levels of IL-2, IL-6, IL-10, TNF-α and IFN-γ, but not IL-17A, in supernatants of PBMC cultures.?Next, apoptosis induction was addressed by using flow cytometry to evaluate annexin V expression.?Treatment with physalin F (10 μM) increased the apoptotic population of PBMC in HAM/TSP subjects.?Transmission electron microscopy analysis of PBMC showed that physalin F induced ultrastructural changes, such as pyknotic nuclei, damaged mitochondria, enhanced autophagic vacuole formation, and the presence of myelin-like figures.?In conclusion, physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by HTLV-1 infection.

Cas No.

57423-71-9

分子式

C28H30O10

分子量

526.538

别名

酸浆苦素 F;酸浆苦味素F

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years