Dihydromyricetin 是一种来自 Ampelopsis GROSsedentata 的天然抗氧化剂类黄酮，是二氢嘧啶酶抑制剂，IC50 为 48 μM。它通过抑制mTOR信号从而激活自噬。它还是流感依赖 RNA 的RNA聚合酶抑制剂，IC50为 22 μM。

Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.

大鼠腹腔注射1 mg/kg Dihydromyricetin中和急性酒精中毒,并且使耐受性,增加的焦虑,惊厥易感的迹象消失. LD50: 腹腔注射小鼠1.41 g/kg.

Dihydromyricetin（1 μM）作为一种新型的抗酒精中毒药物拮抗急性乙醇诱导的GABA（A）Rs和EtOH暴露/撤退诱导的GABA（A）R可塑性增强和GABA（A）R α4亚基在海马和培养的神经元中的表达。Dihydromyricetin有效清除DPPH,还抑制亚油酸系统中FeSO4乙二胺四乙酸催化的脂质过氧化值的增加。

27200-12-0

C15H12O8

320.253

Ampeloptin;Ampelopsin;二氢杨梅素

Ethanol:60 mg/mL (187.4 mM)
H2O:<1 mgml
DMSO:60 mg/mL (187.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years