(-)-Securinine 是来自叶底珠的一种生物碱，也是GABAA受体拮抗剂。

(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.

(-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.

In the tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle-treated mice at the end of the study period.

5610-40-2

C13H15NO2

217.26

一叶秋碱;Securinine

DMSO:2 mg/mL (9.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years