Gimatecan HCl 是一种有效的拓扑异构酶 I (Topoisomerase I) 抑制剂。Gimatecan HCl 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。

Gimatecan HCl is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.

Gimatecan HCl (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency. Gimatecan HCl causes a persistent S-phase arrest At 0.003 μg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 μg/mL)[1].

Gimatecan HCl (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth [1].

T21319L

C25H26ClN3O5

483.94

ST1481 HCL;Gimatecan HCl(292618-32-7 Free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years