LMP744 hydrochloride 是一种是拓扑异构酶 1 抑制剂，显示出抗肿瘤的活性。

LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2].

LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

308246-57-3

C24H25ClN2O7

488.92

MJ-III65 hydrochloride;NSC706744 hydrochloride

DMSO:5.56 mg/mL (11.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years