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Chimmitecan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chimmitecan图片
CAS NO:185425-25-6
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
吉米替康
(S)-9-Allyl-10-hydroxycamptothecin
产品介绍
Chimmitecan是一种Topoisomerase I抑制剂,在体内、外表现有效的活性。

产品描述

Chimmitecan is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.

体外活性

Chimmitecan was highly cytotoxic (IC50s in the nanomolar range) to a wide variety of tumor cells, including leukemia, lung cancer, gastric cancer, hepatocellular cancer, colon cancer, breast cancer, ovarian cancer, and cervical cancer, and rhabdomyosarcoma cells[1].

体内活性

Chimmitecan (i.v. administration, twice for HCT-116 and thrice for the other tumors per week) caused a dramatic and dose-dependent suppression of tumor growth in all four tumor models. At a dosage of 15 mg/kg, the T/C (%) values were 17.6% (HCT-116), 24.2% (MDA-MB-435), 28.2% (BEL-7402), and 23.0% (A549). when given thrice per week for 2 weeks, chimmitecan (orally administration) inhibited the growth of the A549 xenograft at dosages as low as 4.5 mg/kg, and significant antitumor activity was observed at a dosage of 9 mg/kg[1].

Cas No.

185425-25-6

分子式

C23H20N2O5

分子量

404.42

别名

吉米替康;(S)-9-Allyl-10-hydroxycamptothecin

储存和溶解度

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years