(-)-α-Pinene 是一种单萜类化合物，通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。

(1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.

(1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons[1]. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model[1].

7785-26-4

C10H16

136.23

左旋-α-蒎烯;(1S)-(-)-Alpha-Pinene;左旋-alpha-蒎烯

DMSO:50 mg/mL (367.03 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years