Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be an NLRP3 activator that causes the release of IL-1β as a NALP3-dependent manner. Nigericin induces eryptosis, an effect paralleled by ROS formation, and in part due to the induction of oxidative stress. Nigericin causes apoptosis.

28380-24-7

C40H68O11

724.96

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years