Cannabichromene 是一种发现于大麻的 2,2-dimethyl-2H-chromene 衍生物。

Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1.

Cannabichromene (CBC)? activated CB2 but not CB1 receptors to produce hyperpolarization of AtT20 cells.?This activation was inhibited by a CB2 receptor antagonist AM630, and sensitive to Pertussis toxin.?Application of CBC reduced activation of CB2 , but not CB1 , receptors by subsequent co-application of CP55,940, an efficacious CB1 and CB2 receptor agonist.?Continuous CBC application induced loss of cell surface CB2 receptors and desensitization of the CB2 receptor-induced hyperpolarization[2].

20675-51-8

C21H30O2

314.46

大麻色原烯;Cannabichromene;Cannabichrome

DMSO:55 mg/ml (174.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years