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α-Humulene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-Humulene图片
CAS NO:6753-98-6
包装:100 mg
市场价:1180元

产品名称
ALPHA-律草烯
Alpha-caryophyllene
产品介绍
α-Humulene 是Tanacetum vulgareL. 精油的主要成分,显示出抗炎作用,IC50=15±2 μg/mL。它抑制iNOS和COX-2表达。

产品描述

α-Humulene is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression.

体外活性

S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml.

Cas No.

6753-98-6

分子式

C15H24

分子量

204.35

别名

ALPHA-律草烯;Alpha-caryophyllene

储存和溶解度

Ethanol:Soluble
Ether:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years