您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Aurantiamide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Aurantiamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aurantiamide图片
CAS NO:58115-31-4
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
橙黄胡椒酰胺
TMC-58B
产品介绍
Aurantiamide 是马齿苋的活性成分,具有多种生物活性(如抗氧化、抗血小板、抗炎、抗肿瘤活性等),具有口服活性。

产品描述

Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways.

体外活性

Aurantiamide was shown to block the activation of nuclear factor-kappa B (NF-κB) in lipopolysaccharide (LPS)-induced BV2 microglial cells by inhibiting the phosphorylation of the inhibitor kappa B-α (IκB)-α. Aurantiamide decreased the phosphorylation levels of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs).Suggested that aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways[1].Aurantiamide has potent anti-viral and anti-inflammatory effects on IAV-infected cells via inhibition of the NF-κB pathway. Therefore ,Aurantiamide could be a potential therapeutic agent for the treatment of influenza[2].

细胞实验

The anti-viral activity of aurantiamide against Influenza A virus (IAV) was determined using the cytopathic effect (CPE) inhibition assay.?Viruses were titrated on Madin-Darby canine kidney (MDCK) cells by plaque assays.?Ribonucleoprotein (RNP) luciferase reporter assay was further conducted to investigate the effect of aurantiamide on the activity of the viral polymerase complex.?HEK293T cells with a stably transfected NF-κB luciferase reporter plasmid were employed to examine the activity of aurantiamide on NF-κB activation.?Activation of the host signaling pathway induced by IAV infection in the absence or presence of aurantiamide was assessed by western blotting.?The effect of aurantiamide on IAV-induced expression of pro-inflammatory cytokines was measured by real-time quantitative PCR and Luminex assays[2].

Cas No.

58115-31-4

分子式

C25H26N2O3

分子量

402.5

别名

橙黄胡椒酰胺;TMC-58B

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years