alpha-(3,4-Dihydroxyphenyl)lactic acid 具有抗氧化活性，可通过 PI3K/Akt/Nrf2 信号通路增强 HO-1 表达以抑制 6-OHDA 诱导的氧化损伤。

Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways.

The recombinant HCV polymerases used in this study contain the first 570 amino acids of the 591-amino acid native protein sequence, with a six-histidine tag at the N terminus to facilitate purification by affinity chromatography. Briefly, ABT-333 (Dasabuvir) is incubated with 5 to 50 nM polymerase for 15 min at room temperature, follow by the addition of nucleoside triphosphates (NTPs) and [3H]UTP for 3 h at 30°C. After termination of the reaction, the precipitated RNA is captured by filtration through a GF/B filter. The amount of incorporated [3H]UTP is measured by scintillation counting with a Wallac 1450 MicroBeta counter. The percent inhibition is calculated from the initial rates of inhibited reactions relative to that of the uninhibited control reaction. The mean 50% inhibitory concentration (IC50) and the standard error of the mean (SEM) are calculated via nonlinear regression[1].

22681-72-7

C9H10O5

198.174

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years