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Magnesium Lithospermate B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Magnesium Lithospermate B图片
CAS NO:122021-74-3
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
丹參酸B鎂
Monomethyl lithospermate B
Lithospermate B
丹参酸 B 镁
产品介绍
Lithospermate B 是一种咖啡酸四聚体的衍生物,从Salviae miltiorrhizae中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究,并且可以防止葡萄糖引起的细胞内氧化损伤。

产品描述

Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.

体外活性

magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis.?Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3.?More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B.?Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH[1].

体内活性

magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults.administration of MLB significantly attenuated brain edema and neurological deficits after SAH[1].

动物实验

Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model.?MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg[1].

Cas No.

122021-74-3

分子式

C36H28MgO16

分子量

740.909

别名

丹參酸B鎂;Monomethyl lithospermate B;Lithospermate B;丹参酸 B 镁

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years