A-77636 hydrochloride 是一种口服有效的、选择性的和长效多巴胺 D1 受体激动剂 (pKi=7.40; Ki=39.8 nM)，具有抗帕金森病活性。A-77636 hydrochloride 对多巴胺 D2 受体无功能活性。

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM). A-77636 hydrochloride shows antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor.

A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake in male hooded rat, due principally to a reduction in meal size and duration[3].

145307-34-2

C20H28ClNO3

365.89

盐酸A77636;A77636 hydrochloride

H2O:soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years