HIV-1 Integrase inhibitor 8是HIV-1整合蛋白酶抑制剂。

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor.

HIV-1 integrase inhibitor 8 were tested against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay, IC50=275μM and 231μM, respectively. HIV-1 integrase inhibitor 8 were retested using Mg2+ and the IC50 of against strand-transfer (ST) activities was 200μM. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 of 500 μM and 200 μM, respectively. HIV-1 integrase inhibitor 8 induces cell cytotoxicity with LD50 of 20 μM in HeLa cells[1].

1568-80-5

C21H24O2

308.41

DMSO:112.5mg/mL (364.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years