Dimethylacrylshikonin 是一种萘醌衍生物，从Arnebia nobilis中提取得到。它利用PI3K通路诱导 eNOS、VEGF 和 HIF-1α 的表达，促进血管生成，具有抗肿瘤活性。

1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.

24502-79-2

C21H22O6

370.401

Dimethylacrylshikonin;β, β-Dimethylacrylshikonin;β,β-二甲基丙烯酰紫草素

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years