Rubiadin-1-methyl etHER 是一种巴戟天中的蒽醌类化合物，能够抑制 NF-Κb p65 的磷酸化和 IκBα 的降解以及减少 p65 的核转位，阻碍破骨细胞的骨吸收。

Rubiadin 1-methyl ether is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. METHODS AND RESULTS:Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 μM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). CONCLUSIONS:Thus, these compounds could be beneficial in the treatment of diabetes.

7460-43-7

C16H12O4

268.26

Rubiadin 1-methyl ether;3-羟基-1-甲氧基-2-甲基蒽醌

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years