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Eupalinolide K
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eupalinolide K图片
CAS NO:108657-10-9
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
野马追内酯 K
野马追内酯K
[3AR-[3AR*,4R*(E),6E,9S*,10E,11AR*]]-4-羟基-2-甲基-2-丁烯酸 2,3,3A,4,5,8,9,11A-八氢-9-羟基-6,10-二甲基-3-亚甲基-2-氧代环癸五烯并[B]呋喃-4-基酯
产品介绍
Eupalinolide K 是来自野马追的一种倍半萜内酯,是STAT3抑制剂,可作为迈克尔反应受体。

产品描述

Eupalinolide K is a natural product

体外活性

In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3. Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines.

Cas No.

108657-10-9

分子式

C20H26O6

分子量

362.42

别名

野马追内酯 K;野马追内酯K;[3AR-[3AR*,4R*(E),6E,9S*,10E,11AR*]]-4-羟基-2-甲基-2-丁烯酸 2,3,3A,4,5,8,9,11A-八氢-9-羟基-6,10-二甲基-3-亚甲基-2-氧代环癸五烯并[B]呋喃-4-基酯

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years