Neohesperidin dihydrochalcone 是一种合成的糖苷查耳酮，可用作低热量人造甜味剂，添加到各种食品和饮料中。

Neohesperidin dihydrochalcone(NHDC) is an artificial sweetener derived from citrus.

Neohesperidin dihydrochalcone administration causes a significant reduction in the activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone[3]. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day[4].

WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].

20702-77-6

C28H36O15

612.581

Neohesperidin DC;新橙皮苷二氢查尔酮;NHDC;新橙皮苷二氢查耳酮;NCI-c60764

H2O:<1 mgml
Ethanol:100 mg/mL (163.24 mM)
DMSO:100 mg/mL (163.24 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years