Tectol是从Lippia sIDOides中分离的，对人白血病细胞株 HL60 和 CEM 具有显著的抑制作用。它是法尼基转移酶抑制剂，在人和布氏锥虫的IC50分别为 2.09 和 1.73 μM。它具有抗疟原虫活性，是一种中等活性的生长抑制剂，IC50 为 3.44±0.20μM。

Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 of 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatitis, the dermatitis appeared on the neck, upper legs, underarms, and trunk area.

Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone , were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines. Only Tectol and lippsidoquinone exhibited significant activity against human leukemia cell lines HL60 and CEM[1].

24449-39-6

C30H26O4

450.52

DMSO:55 mg/ml (122.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years