2,3-Dihydroxy-4-methoxyacetophenone 是一种从圆锥花草取得的的神经保护化合物。它能够改善认知功能，对阿尔茨海默氏病具有潜在的研究价值。

2,3-Dihydroxy-4-methoxyacetophenone is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine.?In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine.?2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM).?Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity.?2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity.?2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

708-53-2

C9H10O4

182.17

2,3-二羟基-4-甲氧基苯乙酮水合物;2',3'-Dihydroxy-4'-methoxyacetophenone

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years